I use it in my 1999 NSX and 1977 MB.  I have had not problems.  The
primary reason I use it is these are low milage cars and I only change
the oil once a year.  On cars where I change it twice a year I use
regular oil.  I haven't noticed any great benefit from using it except
for longevity.

I use synthetic in all my cars 'cause I do my own oil changes and the
fewer oil changes I do the better.  Synthetic has advantages for
drivers who use all those RPMs (high heat) or live where it gets very
cold (synthetic flows MUCH better during cold starts). Most drivers do
fine with conventional oils changed twice a year as suggested by Mr.
Peirce. I'll make an exception for any car with a turbo charged
engine; synthetic is the only way to go (high heat situation). Use the
viscosity suggested in your owner's manual. I admit to avoiding those
new tea-cup sized Honda oil filters, though.