While I profess ZERO experience here, a few recent weeks of intense
research and learning on this topic offers the following insights:

1) Unless all this is being hauled/towed with a dually, a set of G-rated
tires ($$$) on the back of the truck might save you from the expense and
inconvenience of tread-separation and catastrophic tire failure going down
the road someday.

2) Get the whole kit & kaboodle on a truck scale somewhere and make very
sure the total COMBINED weight of the truck & passengers & fuel & supplies
w/slide-in camper on it *AND* the fully loaded trailer with all supplies &
water, etc. does not total more than the truck manufacturer's maximum GCWR
rating number. The "GCWR" number is the one that will bite you. (GCWR =
Gross Combined Weight Rating)

As I begin to pursue this RV thing myself I'm learning a great deal of
info. Among those newly-gleaned tidbits is that the cops are not as dumb
as they look. Go rolling across Iowa, Illinois, Indiana or California with
an "obviously heavy" looking non-commercial vehicle (pickup truck) and the
STATE cops are almost certain to stop you and escort you to a weigh
station. I don't know about the other states, but in Illinois the fine for
being over GCWR is $2500 and you cannot proceed on your way until you shed
the excess pounds. I'm guessing this rule might be similar inother states.