Yes, IF the motor was originally a 5.0. That's about when the newer style F-150 came
out using the 4.2 or 4.6, I honestly don't remember exactly when. If that is what you
have, it won't work. If the truck is still the earlier body style you will need to use
the "new" engine as a long block. Reuse the "old" intake and exhaust manifolds,
accessory train, oil pan and pickup tube, etc. Basically strip the "new" motor down to
the block and heads and reuse everything else from the "old" motor. This would be a
great time to completely reseal the new motor.
 The more I think about it, I think you might have the newer style truck. Are you
looking to replace a blown 4.2? If this is the case, no, the 5.0 won't work.

Anything is possible with enough $$$.

You will need a donor 1996 F-150 w/ 5.0 harnesses & computers for the
OBDII, & probably the transmission.  You will have to do some mount &
shaft fabrication, even moreso if you are contemplating 4wd.

You will come out FAR ahead getting a salvaged engine that is a perfect
replacement - they're quite cheap & plentiful.

Rob

Not without reprogramming the microprocessor.

Mike hunt