Do you hear anything when you turn the ignition key? That is, can you hear
the starter motor turning the engine, but the engine just won't catch?

If so, check for spark at the plugs, first. There are many sites on the web
that describe this.

Check for symptoms of a bad main relay, too per Tegger's
www.tegger.com/hondafaq site.

Report back.

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Honda home studies: http://home.earthlink.net/~honda.lioness
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If spark/timing/fuel OK, head/headgasket likely toasted.